Postdoctoral Researcher in Cancer Biology
We are seeking a motivated postdoctoral biologist with background in cancer biology who will join the team of Dr. Soucek at the International Clinical Research Center of St. Anne´s University Hospital in Brno (FNUSA – ICRC). Selected candidate will investigate the pathological plasticity and heterogeneity of tumors, its role in cancer dissemination and therapy resistance.
Work Assignment: 1 FTE Start Date: April 2017
The International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC), Czech Republic is a new-generation research center focusing on the pathogenesis of diseases including finding new methods, technologies and medicaments for effective prevention, early diagnostics and individualized treatment.
We are a top Central European research center with more than 200 researchers, new technologies and experience in using EU grant support. We focus on research and development mainly in the fields of cardiovascular and neurological diseases. Our partners are world-class research centers and universities. For more reference, you can see our website: http://www.fnusa-icrc.org/en/
About Cancer Plasticity Group (CAP)
Cancer Plasticity Group (CAP), headed by Dr. Karel Souček, is located at Department of Cytokinetics, Institute of Biophysics of the CAS and provides a dynamic research environment with state-of-the-art facilities. CAP is a part of a unique interdisciplinary research platform - Centre of Biomolecular and Cellular Engineering (CBCE), which represents one of the research platforms of International Clinical Research Centre (ICRC). The CBCE platform focuses on research of biologically active small molecules and engineered proteins, which currently represent the most promising tools for influencing biological processes such as genomic cell stability, cell growth, differentiation, survival and cell death, and cell reprogramming to pluripotency. Main research topics are:
- Correlation of the plasticity of cancer cells with aberrant signaling in cancer cells, dissemination capability and chemoresistance.
- Description of heterogeneity of expression of markers defining most aggressive cells at single cell level within tumor.
- Introduction of methods for expansion of clinical samples maintaining its original phenotype (e.g. patient-derived xenografts, 3D in vitro cultures of organoids/tumoroids).
To achieve these goals we use various in vitro and in vivo models including complex analysis of cytokinetics (analysis of proliferation, differentiation and cell death) and phenotype heterogeneity using variety of methods and approaches including single cell analysis techniques and pre-clinical in vivo imaging of tumor progression using immunodeficient mice.
Oncotarget 6, 36156-36171, (2015).
Molecular Cancer 13, (2014).
Cytometry A 83, 472-482, (2013).
Cell. Signal. 24, 1665-1676, (2012).
Neoplasia 13, 526-536, (2011).
Cell. Signal. 22, 1734-1744, (2010).
- solid knowledge of cell & molecular biology and biochemistry
- good laboratory practice habits
- high motivation and enthusiasm
- team oriented with good communication skills
- proficiency in English language
- Working in international multidisciplinary team
- Opportunities for further education and training
- 5 weeks of holidays
- Fixed-term contract (initial 1 year contract with extension up to 3 years)
How to apply:
You are invited to send your CV including a publication list, cover letter describing motivation and previous experience and 2 contacts for recommendation to: firstname.lastname@example.org.
Deadline is 20 March 2017. We are looking forward to hearing from you!
All received applications will be reviewed carefully, with focus on the excellence of candidates. Shortlisted will be contacted further and invited for an interview.
We are pleased to consider all qualified applicants for employment without regard to age, gender, marital status, sexual orientation, race, color, religion, ethnicity, disability, national origin, nationality, political opinion or any other aspect unrelated to work.
By responding to this invitation and/or sending your CV and any other personal materials to St. Anne's University Hospital, you consent to the collection, processing and storage of your personal data in accordance with Act No. 101/2000 Coll., the protection of personal data. You are providing St. Anne's University Hospital with these data solely for the purpose of mediating employment, the period however being no longer than one year from submitting. Should you not reclaim the materials submitted by you, they will be discarded after the period has expired.