Dementia (DEM/Neuro 2)

prof. doc. MUDr. Jakub Hort, Ph.D.

Principal Investigator


zástupce MUDr. Kateřina Sheardová

Contact to Assistant

Ing. Monika Kurečková, e-mail:, phone: +420 543 184 086 
(PhDr. Daria Hudspeth, e-mail:

Research team


The subprogram is focused on establishing large multi-center databases related to the epidemiology of neurological diseases.


  • The establishment of a data repository (FNUSA-ICRC, Motol University Hospital, Mayo Clinic) that describes longitudinal changes in the brain structure and metabolism in healthy elderly patients, mild cognitive impairment patients, and Alzheimer’s disease patients.
  • The creation of a biological sample bank where blood samples will be collected and stored for future genetic analysis and cerebrospinal fluid samples stored for biomarker evaluation in patients with Alzheimer’s disease.
  • The creation of a cognitive data repository using specific neuropsychology protocols and tools for testing hippocampus-related memory impairment as an early specific sign of Alzheimer’s disease.
  • The creation of an MRI database for the longitudinal study of brain atrophy in patients with cognitive impairment; the implementation of advanced MRI techniques in the differential diagnosis of dementia.


  • FNUSA-ICRC Science fo Helth: Support of Clinical Research Popularization (ECOP)
  • Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge, FP7)
  • ICRC Human Bridge - Support of Study Stays of Czech Researchers Abroad II: Young Talent Incubator (ECOP)
  • ICRC PartnerNet - Research Partnership Network (ECOP)
  • MEDINFO - Information Sources for Medicine and Related Fields (R&DI OP)


Profile list of research team