Acute Coronary Syndromes (ACS/Cardio 2)

MUDr. Ota Hlinomaz, CSc.

Principal Investigator


Contact to Assistant

Lucie Knoppová, e-mail: lucie.knoppova@fnusa.cz


Research team


Profile

Coronary heart disease (CHD) remains the leading cause of mortality in the Czech Republic. The subject of our research particularly involves acute forms of the disease, i.e., acute myocardial infarction and unstable angina pectoris. Since percutaneous coronary intervention (PCI) is the most effective method of treatment, we focus on the early diagnosis of CHD and the development of new imaging techniques, as well as that of new PCI techniques and materials, especially intracoronary stents, which are used during PCI.   

Main research areas

  • The coronary heart disease therapy, focusing on acute myocardial infarction.
  • The development of new coronary stents and artificial blood vessels using bio- and nanotechnologies permitting longer life of the material and its better acceptance by the body.
  • The development of a registry to compare different treatments in patients with acute myocardial infarction and consequent significant stenosis of the non-infarct-related coronary artery.
  • Research on the causes of stent thrombosis.
  • Effects of platelet aggregation on the prognosis in patients with acute coronary syndrome.
  • The use of stem cells in the treatment of acute myocardial infarction.

Application of the results

  • Bio-compatible stents and artificial blood vessels with longer life.
  • Reduced incidence of life-threatening complications of stent implantation.
  • State-of-the-art treatment of acute coronary syndromes.

Technology background

  • Optical coherence tomography - a non-contact and non-invasive tomographic imaging and diagnostic method that displays, in extremely high quality of micrometer resolution, images of biological tissue (a thin layer of the skin and mucous membranes, eyes and teeth) in their transverse section.
  • Angiographic line – to examine patients with cardiac valvular apparatus disorder before the planned surgery.
  • Coronary stents – a reinforcement made of a special metal alloy that is typically introduced in patients after myocardial infarction via a catheter into narrowed or clogged arteries supplying the heart muscle with blood.

Cooperation

Czech Republic

  • Tomas Bata Regional Hospital
  • General University Hospital in Prague
  • University Hospital “Královské Vinohrady“, Prague
  • University Hospital Motol, Prague

World

  • Mayo Clinic (USA)
  • Bulgarian Cardiac Institute Jambol (Bulgaria)
  • Bulgarian Cardiac Institute Pleven (Bulgaria)
  • Bulgarian Cardiac Institute Varna (Bulgaria)
  • Bulgarian Cardiac Institute Veliko Tarnovo (Bulgaria)
  • German Heart Center Munich (Germany)
  • Jagellonian University Krakow (Poland)
  • The University Hospital Krakow (Poland)
Projects
  • FNUSA-ICRC Science fo Helth: Support of Clinical Research Popularization (ECOP)
  • Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge, FP7)
  • ICRC Human Bridge - Support of Study Stays of Czech Researchers Abroad: Young Talent Incubator (ECOP)
  • ICRC PartnerNet - Research Partnership Network (ECOP)
  • MEDINFO - Information Sources for Medicine and Related Fields (R&DI OP)
  • Multivessel coronary disease diagnosed at the time of primary PCI for STEMI: complete revascularization versus conservative strategy. PRAGUE - 13 trial (IGA MZ ČR)