Tissue engineering (TEG/Cardio 7)

MUDr. Pavel Piler

Principal Investigator


Contact to Assistant

Anna Životská, e-mail: anna.zivotska@fnusa.cz

Ing. Anna Zrnečková, e-mail: anna.zrneckova@fnusa.cz, phone: +420 543 184 074

 

Research team


Profile

Every year, there is a large number of surgeries around the world to replace damaged heart valves. This was so far done using two methods, with either tissue valve made of biological tissues (porcine valves or bovine pericardium) or mechanical valves implanted to the patient. The advantage of a tissue heart valve is in that the patient does not have to take anticoagulants, thus is not at risk of developing a blood clot or bleeding, such as from peptic ulcer or into the brain. However, a disadvantage involved is that these valves degenerate, meaning that the patient must, after some time (which is individual, but 10 to 15 years apply in general), undergo another challenging operation. The other method makes use of mechanical valves, but, although these are permanent, the patient remains after the implantation dependent on anticoagulant therapy until the end of their life, which poses restraints in the number of activities, reducing the quality of life. If it can be proved that the heart valve from a genetically modified pig is not prone to degeneration, it could replace in the future not only the conventional valve, but also the mechanical valve, which might present a significant benefit for the patient. To achieve this, the genetically modified tissues need to be implanted to other animals and then the response of the creature, e.g. in terms of immunology, has to be examined. Such implantations require performing the surgery in the extracorporeal circulation with stopped heart. 

Main research areas

  • the development of novel artificial biological valves and other tissues,
  • research in the field of xenotransplantations (interspecies organ transmission) and the resulting outcomes for human medicine and therapeutic methods.

Application of research results

  • the development of new methods for examination and preservation of biological tissues,
  • the use of biological tissue substitutes for human tissue with applications in cardiology, cardiac surgery and transplantation medicine,
  • the improvement of technique of animal experiments – surgeries of bigger animals, particularly of pigs in extracorporeal blood circulation.

Technology background

  • experimental animal center built at the premises of the University of veterinary and pharmaceutical science Brno which provides a sufficient environment for experiments on bigger animals in extracorporeal blood circulation.

Cooperation

Czech Republic

  • University of veterinary and pharmaceutical sciences Brno

World

  • University College London (Great Britain)

Projects

  • FNUSA-ICRC Science fo Helth: Support of Clinical Research Popularization (ECOP)
  • Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge, FP7)
  • ICRC Human Bridge - Support of Study Stays of Czech Researchers Abroad: Young Talent Incubator (ECOP)
  • ICRC PartnerNet - Research Partnership Network (ECOP)
  • MEDINFO - Information Sources for Medicine and Related Fields (R&DI OP)

Publications

Profile list of research team