Non-invasive Cardiovascular Imaging (Cardio 5)

MUDr. Marek Orban

National Coordinator

prof. Andreas Melzer, M.D.

International Coordinator


Contact to Assistant

Bc. Veronika Kolaříková,  e-mail: veronika.kolarikova@fnusa.cz


Research team


Profile

The aim of the subprogram is to provide technology and training for the integration of ultrasound and biophotonics-based imaging guidance with Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and Positron Emission Tomography (PET) to define the specifications of an Interventional Imaging Operating Network aimed at early detection and minimally invasive treatment of cardiovascular disease, particularly coronary heart disease, heart failure, cardiac arrhythmias, and structural heart defects. The subprogram will be conducted in collaboration with the University of Dundee and the IIIOS Network.

Main research areas

  • Imaging methods: MRI, CT, echocardiography.
  • Specialized imaging methods (echocardiography - stress tests, contrast echocardiography, speckle tracking echocardiography, 3D echocardiography, interventional procedures navigated using MRI).
  • Development of new strategies for the assessment of myocardial perfusion by comparing the results of MRI and echocardiography modalities.
  • Development of a new contrast agent with specific properties for the evaluation of myocardial perfusion.
  • Development of a new injection pump used for administration of a contrast agent in the respective quantities.
  • Research in the field of experimental cardiology including preclinical research.
  • Development of animal models used for intervention actions with the use of imaging techniques.

Application of the results

  • Development of a new contrast agent for the evaluation of myocardial perfusion.
  • Development of a new injection pump for administration of a contrast agent in the respective quantities.
  • Testing prototypes used for performing MRI-controlled intervention.

Technology background

  • Ultrasound Center including, for instance, ultrasound tomography, ultrasound equipment with a 3D transesophageal probe and ultrasound equipment - echo, used for determining the structure and function of the heart by means of transthoracic and transesophageal imaging by new techniques such as 3D echo, contrast echocardiography, strain and strain rate analysis.
  • MRI - a complete spectrum of cardiology clinical applications, detection and determination of the proportion of myocardial fibrosis and prognostic stratification; the creation of new MRI sequences for Real-time display using Research key with subsequent use in surgical interventions.
  • CT - a complete spectrum of clinical cardiology applications, non-invasive diagnosis of ischemic heart disease, and determination of the prognostic significance of the finding, non-invasive determination of significance of the coronary artery stenosis.
  • The multimodal center for the animal experiments (VFU Brno) - the study of pathophysiology of cardiovascular diseases, testing new approaches and interventional tools in animal models using a combination of available modern imaging modalities (MRI, TTE, TEE, ICE, X-ray scan).

Projects

  • FNUSA-ICRC Science fo Helth: Support of Clinical Research Popularization (ECOP)
  • Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge, FP7)
  • ICRC Human Bridge - Support of Study Stays of Czech Researchers Abroad: Young Talent Incubator (ECOP)
  • ICRC PartnerNet - Research Partnership Network (ECOP)
  • MEDINFO - Information Sources for Medicine and Related Fields (R&DI OP)

Publications