Stroke (STK/Neuro 1)

Doc. MUDr. Robert Mikulík, Ph.D.

Principal Investigator


Contact to Assistant

Ing. Michaela Oudová, Dis., e-mail: michaela.oudova@fnusa.cz, phone: +420 543 185 587

 


Reserch team


Profile

Acute stroke is the world's second leading cause of death and the most frequent cause of disability among older patients. Prevention and treatment form two fundamental pillars in fighting against the disease Despite great advances in the management of cerebral infarction in recent years, the treatment of this serious disease is still unsatisfactory. Continuous research on new possibilities of diagnosis, therapy and prevention is the only way to improve, thus having an increased number of self-sufficient patients. For this reason, we not only participate in specific international research protocols, but also initiate a number of these ourselves in collaboration with domestic and foreign institutions, both in clinical practice and experimentally under laboratory conditions.

Main research areas

  • Epidemiology of cerebral infarction in the Czech Republic.
  • Education and awareness-raising among the general public about the symptoms and treatment of cerebral infarction.
  • Development of new algorithms for the diagnosis of cerebrovascular disease based in particular on multimodal imaging.
  • Development of new therapeutic algorithms relating to recanalization methods, support of collateral circulation, interventional therapy (both in the clinical practice and experimentally in the laboratory).
  • Improved rehabilitation after stroke.

Goals

  • Increased awareness among the public brings faster transfer of patients with acute cerebral infarction into facilities with available therapy, thereby increased effect of the therapy.
  • Development of effective prevention approaches reduces the incidence of cerebrovascular events in the population.
  • Diagnosis acceleration and increased precision makes the administered therapy faster and more efficient, while allowing individualization of the treatment, i.e. opting for the most appropriate medical procedure for particular patients.
  • Making the therapy more effective  alleviates severity of the damage caused by stroke, increasing the patient's chances of recovery (independent life after stroke).
  • Studies into epidemiology contribute to all the above points, thus supporting the overall improvement of care as regards patients with cerebrovascular disease.

Technology background

Implementing all the models to improve the care of patients with cerebrovascular disease will benefit from the technology equipment needed:

  • Neurological "bi-plane" angiography line
  • Devices to monitor life-threatening conditions
  • Ultrasound units for both extra and transcranial diagnosis of arterial disease
  • Available will also be new and more powerful CT and MRI devices, X-ray units with direct digitization, PET and SPECT units
  • Rehabilitation equipment - ultrasonic and magnetotherapy units, multifunctional baths, vertical beds, inclined planes with an integrated robotic System for walking, robotic systems to activate postural and locomotor mechanisms

Collaboration

Czech Republic

  • Institute of Scientific Instruments of the CAS, v. v. i.
  • Veterinary Research Institute
  • Institute of Biophysics of the CAS, v. v. i.
  • Masaryk University, Faculty of Social Studies
  • Masaryk University, Faculty of Education MU
  • Institute of Health Information and Statistics of the Czech Republic
  • IKTUS o.p.s.
  • ICTUS HELP

World

  • Karolinska Institutet (Sweden)
  • University of Calgary (Canada)
  • Mayo Clinic, Rochester (USA)
  • Columbia University Medical Center (USA)
  • Vall d´Hebron Research Institute and Hospital (Spain)
  • European stroke organization

Industrial

  • Robotsystem s.r.o.
  • BioVendor - Laboratorní medicína a.s.

Projects

  • RESSTORE - REgenerative Stem cell therapy for STroke in Europe (H2020, European Commission)
  • FNUSA -ICRC - Support for neurological R&D teams through new postdoc positions formation (ECOP)
  • HOBIT - HOdina BIologie pro živoT: Implementace problematiky cerebrovaskulárních a kardiovaskulárních onemocnění do školního vzdělávacího plánu (ECOP)
  • Human Bridge for Strengthening Integration of ICRC into European Research Area (ICRC-ERA Human Bridge, FP7)
  • ICRC Human Bridge - Support of Study Stays of Czech Researchers Abroad II: Young Talent Incubator (ECOP)
  • IKTA partnership and network (ECOP)

Publications

Profile list of research team