Monocytes and septic shock

Sepsis and septic shock are among the most common complications in intensive care units. The WHO identifies sepsis as one of the major global health problems. During research coordinated by Dr. Jan Frič, PhD., the team of authors focused on elucidating the dynamics of the occurrence of individual subpopulations of monocytes in patients with septic shock. The results were published by the research team in the Journal of Cellular and Molecular Medicine in an article entitled “Differences in monocyte subsets associated with short-term survival in patients with septic shock.

This project, in which the Cellular and Molecular Immunoregulation (CMI) Research group from the Center for Translational Medicine participated, together with the Intensive Care Research (INC) Research group and colleagues from the Department of Anaesthesiology and Resuscitation at the St. Anne’s University Hospital Brno and Faculty of Medicine MU, confirms the excellent connection between the clinical and research part of the St. Anne’s University Hospital Brno. FNUSA-ICRC received funding for this research from grants from the Ministry of Health of the Czech Republic (AZV) and the European Union (ENOCH and MAGNET).

Monocytes are activated in the very early stages of the development of septic shock – on the order of hours, so they can be considered as the first sensors of developing septic shock. The incidence of individual monocyte subpopulations is associated with the prediction of survival in patients with septic shock. It is this specific profile of monocyte subpopulations that can be observed in patients within the first hours of their admission to the ICU. These data could be used to identify at-risk patients who do not respond to conventional treatment, but could benefit from specific tailor-made treatment.

You can find the article here: https://pubmed.ncbi.nlm.nih.gov/32949213/, or via QR code.